Seems to work perfectly so far, though I've not been able to test actually starting any chapters so far, since.. well, I'll be recording my let's play tomorrow and I intend it to be blind, like my Saira playthrough.
Either way, some information:
Distribution: Arch Linux, stock kernel, version 3.6.10-1, 64-bit
CPU: Intel i5 (the first generation, 750)
RAM: 8GB DDR3
GPU: Nvidia GTX 580
Monitors: Dual-monitor setup using TwinView, game handles full-screen perfectly well
Sound card: ASUS Xonar Essence ST via PulseAudio using ALSA as its backend
Also, terminal output just on the off-chance it'll be of use:
[alan@alanhome Knytt Underground]$ ./run.sh
Audio initialized: 1.1 ALSOFT 1.14, OpenAL Soft, OpenAL Community
Framerate: 70.5368
Setting image file to: ./World/Sprites.dat
Loading ./Game.ini (Game.ini)
Loading ./World/World.ini (World.ini)
Loading ./World/Objects/Objects.ini (Objects.ini)
Loading ./Settings/Settings - Chowdren Linux.ini (Settings.ini)
Loading ./Data/Default Settings/Chowdren Linux.ini (Default Settings Ini)
Loading ./Settings/Nifflas - Default World, Achievements.ini (Achievements Savedata)
INI load failed (./Settings/Nifflas - Default World, Achievements.ini) with code -1
Loading ./World/Achievements/Achievements.ini (Achievements.ini)
Loading ./Data/Keyboard/Chowdren Linux.ini (Keyboard Ini)
Loading ./World/Creatures.ini (Creatures.ini)
Loading ./World/Characters/Characters.ini (Characters.ini)
Loading ./World/Dialog/Dialog.ini (Dialog Ini)
Loading ./World/Dialog/Chowdren.ini (Dialog Ini)
Loading ./World/Dialog/Juni's Umbrella.ini (Dialog Ini)
Loading ./World/Dialog/Susanna's Gems.ini (Dialog Ini)
Loading ./World/Dialog/Megabyte Village.ini (Dialog Ini)
Loading ./World/Dialog/Christina.ini (Dialog Ini)
Loading ./World/Dialog/The Hard Disk.ini (Dialog Ini)
Loading ./World/Dialog/The Family.ini (Dialog Ini)
Loading ./World/Dialog/Utopioca.ini (Dialog Ini)
Loading ./World/Dialog/Chico.ini (Dialog Ini)
Loading ./World/Dialog/Children of The Rig.ini (Dialog Ini)
Loading ./World/Dialog/Professor Julie.ini (Dialog Ini)
Loading ./World/Dialog/Paradise.ini (Dialog Ini)
Loading ./World/Dialog/Johann.ini (Dialog Ini)
Loading ./World/Dialog/Cilia's Family.ini (Dialog Ini)
Loading ./World/Dialog/Semiaquatics.ini (Dialog Ini)
Loading ./World/Dialog/Ionel's Museum.ini (Dialog Ini)
Loading ./World/Dialog/Secrets.ini (Dialog Ini)
Loading ./World/Dialog/Moonshine.ini (Dialog Ini)
Loading ./World/Dialog/Double Armageddon.ini (Dialog Ini)
Loading ./World/Dialog/Ball Lab Escape.ini (Dialog Ini)
Loading ./World/Dialog/Illumine.ini (Dialog Ini)
Loading ./World/Dialog/Lauritz.ini (Dialog Ini)
Loading ./World/Dialog/Mi's Family.ini (Dialog Ini)
Loading ./World/Dialog/Malie.ini (Dialog Ini)
Loading ./World/Dialog/Red Intro And Ending.ini (Dialog Ini)
Loading ./World/Dialog/The Incident with The Metal Pineapples.ini (Dialog Ini)
Loading ./World/Dialog/The Mage.ini (Dialog Ini)
Loading ./World/Dialog/Spiro.ini (Dialog Ini)
Loading ./World/Dialog/Avocado Transport.ini (Dialog Ini)
Loading ./World/Dialog/Hannah.ini (Dialog Ini)
Loading ./World/Dialog/Pat The Fairy.ini (Dialog Ini)
Loading ./World/Dialog/Wangleflower.ini (Dialog Ini)
Loading ./World/Dialog/Fiber Optic.ini (Dialog Ini)
Loading ./World/Dialog/Blubleblu.ini (Dialog Ini)
Loading ./World/Dialog/The Insanity.ini (Dialog Ini)
Loading ./World/Dialog/Spectral Diamond.ini (Dialog Ini)
Loading ./World/Dialog/Care Centre.ini (Dialog Ini)
Loading ./World/Dialog/Bluestone.ini (Dialog Ini)
Loading ./World/Dialog/Blue Ending.ini (Dialog Ini)
Loading ./World/Dialog/Dora's Home.ini (Dialog Ini)
Loading ./World/Dialog/Pixies.ini (Dialog Ini)
Loading ./World/Dialog/Bell Tower Entry.ini (Dialog Ini)
Loading ./World/Dialog/Chidi.ini (Dialog Ini)
Loading ./World/Dialog/Green Ending.ini (Dialog Ini)
Loading ./World/Dialog/Knytt Warrior.ini (Dialog Ini)
Loading ./World/Dialog/The Twilight Zone.ini (Dialog Ini)
Loading ./World/Dialog/Rob.ini (Dialog Ini)
Loading ./World/Dialog/Place Introductions.ini (Dialog Ini)
Loading ./World/Dialog/Leave Bell Tower.ini (Dialog Ini)
Loading ./World/Dialog/Commentary.ini (Dialog Ini)
Loading ./World/Dialog/Crystal Trading.ini (Dialog Ini)
Loading ./World/Dialog/Interlude.ini (Dialog Ini)
Loading ./World/Dialog/Menu.ini (Dialog Ini)
Loading ./World/Dialog/Juni and The Puzzle Piece.ini (Dialog Ini)
Loading ./World/Dialog/Demo.ini (Dialog Ini)
Loading ./World/Dialog/Tova.ini (Dialog Ini)
Loading ./World/Dialog/Neon Fall.ini (Dialog Ini)
Loading ./World/Dialog/Myriadist Leaders.ini (Dialog Ini)
Loading ./World/Dialog/Time Keeper.ini (Dialog Ini)
Loading ./World/Dialog/Fairy Spring.ini (Dialog Ini)
Loading ./World/Music/Music.ini (Music.ini)
Loading ./World/Sounds/Sounds.ini (Sounds.ini)
Loading ./World/Ambiance/Ambiance.ini (Ambiance.ini)
Event update took 0.41147
Loading ./World/Cache.ini (Cache.ini)
Loading ./World/Default Saves/Menu.ini (Savedata)
Loading ./World/Items/Inventory (Red).ini (Inventory ini)
Framerate: 59.6979
Event update took 0.002839
Draw took 0.008839
Framerate: 59.7872
Event update took 0.002853
Draw took 0.008467