A 100% run should definitely include having the entire map visible and all objects you can find on each screen. I think it should be limited to the 3rd chapter only, given that it contains the areas of chapter 1 and 2. But given that for a new game you need to do them, it would mean, get past them as quickly as possible.
If all screens is not a requirement, atleast all items (indicated with an i on the map).
I would exclude the secret areas though, that means you don't need the recepe either. I think the enigma could be in the run, but its also part of a secret.